The invention discloses a toothpaste special for pregnant women, which is prepared by taking a perilla extract or perilla volatile oil, a bighead atractylodes rhizome extract, a scutellaria baicalensis extract, vitamin B6, and other medicinal material extracts as main medicament active raw materials, blending normal auxiliary materials and the raw materials, and performing conventional process onthe materials. The toothpaste special for pregnant women has the advantages of effectively preventing the pregnant women from vomiting during teeth brushing and effectively preventing and relaxing symptoms such as pregnancy gingivitis, pregnancy gingivaltumor, periodontitis, tooth decay, dental ulcer and the like.