The invention discloses a compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof. The compound medicinal composition for treating the livestock and poultry respiratory disease mainly comprises the following components in part by weight: 1 to 3 parts of tiamulin hydrogen fumarate, 5 to 15 parts of doxycycline hydrochloride, 1 to 15 parts of astragalus polysaccharide and 1 to 4 parts of antisepsis synergist. In the compound medicinal composition for treating the livestock and poultry respiratory disease, the tiamulin hydrogen fumarate and the doxycycline hydrochloride are adopted, and the antisepsis synergist is added, so the antiseptic effect of the medicament is improved on the basis of maintaining the medicinal effects of the tiamulin hydrogen fumarate and the doxycycline hydrochloride, and the aims of high efficiency and quick response are fulfilled; besides, the added traditional Chinese medicinal component astragalus polysaccharide adjusts the physiological function of the livestock and poultry, improves the immunity of the livestock and poultry, and improves the antiseptic capacity of organisms of the livestock and poultry.