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发明授权
CN101947321B 活疫苗用耐热冻干保护剂及其制备方法及鸡新城疫活疫苗 失效 - 权利终止 转让

活疫苗用耐热冻干保护剂及其制备方法及鸡新城疫活疫苗
摘要：
本发明公开了一种活疫苗用耐热冻干保护剂及其制备方法，以及采用该冻干保护剂的鸡新城疫活疫苗，其中活疫苗用耐热冻干保护剂是由以下重量百分含量的组分组成：海藻糖10-15%，聚乙烯吡咯烷酮（PVP）1-2%，明矾1-2%，谷氨酰胺1-2%，山梨醇2-10%，磷酸二氢钾0.1-0.5%，维生素C 0.5-1%，余量为水。本发明的活疫苗用耐热冻干保护剂，与传统疫苗相比具有稳定性好、保存时间长、保存条件低、活疫苗的活性损伤小、溶解性好、原料简单等优点。
摘要（英）：

The invention discloses a heat-resisting and freeze-drying protector for a live vaccine and a preparation method thereof as well as a live newcastle disease vaccine adopting the freeze-drying protector. The heat-resisting and freeze-drying protector for the live vaccine comprises the following compositions in percentage by weight: 10-15 percent of trehalose, 1-2 percent of polyvinylpyrrolidone (PVP), 1-2 percent of alum, 1-2 percent of glutamine, 2-10 percent of sorbitol, 0.1-0.5 percent of potassium dihydrogen phosphate, 0.5-1 percent of vitamin C and the balance of water. Compared with the traditional vaccine, the heat-resisting and freeze-drying protector for the live vaccine has the advantages of good stability, long preservation time, low preservation condition, little activity damage on the live vaccine, good dissolubility, simple raw material and the like.

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