The invention discloses a biodegradable medicament-loaded polymer scaffold and a preparation method thereof and belongs to the field of medical apparatus and instruments. The polymer scaffold comprises a scaffold body and a medicament-loaded coating, wherein the scaffold body is prepared from aliphatic polycarbonate with biodegradability and/or copolymer or blend thereof; and the medicament-loaded coating is a mixture of an antiproliferative medicament and the aliphatic polycarbonate with biodegradability and/or the copolymer or the blend thereof. The preparation method comprises the following steps of: preparing the scaffold body, preparing coating liquid and preparing the medicament-loaded coating. The polymer material is the biodegradable aliphatic polycarbonate with biodegradability and/or copolymer/blend prepared from the biodegradable aliphatic polycarbonate and cyclic anhydride, lactone, lactide, phosphate, dioxane, amino acid, polyether and the like, wherein the polymer material has the characteristics of no toxin, high biocompatibility and the like, surface corrosion degradation mode, and capacity of effectively avoiding collapse of polylactic acid materials. The scaffold can be degraded and absorbed by a human body and degraded products are nontoxic.