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发明公开
CN101948791A 一种溶藻弧菌野生毒株的无标记基因缺失减毒突变株、相关制剂及应用 无效 - 撤回

一种溶藻弧菌野生毒株的无标记基因缺失减毒突变株、相关制剂及应用
摘要：
本发明涉及一种溶藻弧菌野生毒株的无标记基因缺失减毒突变株，它是溶藻弧菌毒株的减毒活疫苗，其中缺失了溶藻弧菌毒株的sRNA分子伴侣蛋白基因hfq，溶藻弧菌毒株是溶藻弧菌毒株EPGS020401，保藏号为：CCTCC No.AB209306，还提供了上述溶藻弧菌野生毒株的无标记基因缺失减毒突变株的制剂，及相关的在防治养殖鱼类的溶藻弧菌病中应用，本发明的溶藻弧菌野生毒株的无标记基因缺失减毒突变株或相关制剂消除了传统减毒活疫苗普遍存在的潜在环境和产品安全风险，是针对养殖鱼类的溶藻弧菌病的一种安全、有效、经济的疫苗。
摘要（英）：

The invention relates to a marker-free gene deletion attenuated mutant of a vibrio alginolyticus wild strain. The mutant is an attenuated live vaccine of the vibrio alginolyticus wild strain, wherein sRNA molecular chaperone protein gene hfq of the vibrio alginolyticus wild strain is deleted; and the vibrio alginolyticus wild strain is the vibrio alginolyticus wild strain EPGS020401 with a collection number of CCTCC No. AB209306. The invention also provides a preparation of the marker-free gene deletion attenuated mutant of the vibrio alginolyticus wild strain and related application to prevention and treatment of vibrio alginolyticus diseases of cultured fishes. The marker-free gene deletion attenuated mutant of the vibrio alginolyticus wild strain or the related preparation eliminates common potential security risk of environment and product existing in the conventional attenuated live vaccine, and is a safe, high-efficiency and economic vaccine aiming at the vibrio alginolyticus diseases of the cultured fishes.

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