The invention relates to a plant medicinal composition for inhibiting angiogenesis in breast cancer cells and a preparation method thereof. The medicinal composition comprises the following raw materials in percentage by weight: 16 to 30 percent of barbed skullcap herb, 16 to 30 percent of spreading hedyotis herb, 8 to 20 percent of Indian buead, 8 to 18 percent of baical skullcap root, 8 to 15 percent of large-headed atractylodes rhizome, 8 to 12 percent of coix seed, 5 to 12 percent of tangerine peel, 4 to 10 percent of Indian iphigenia bulb, 4 to 8 percent of notoginseng root, 3 to 6 percent of safflower, 1 to 5 percent of Chinese alangium root and 2 to 4 percent of calonyction choisy. Extract is obtained by different extracting methods, and the plant medicinal composition can be prepared into any common oral formulations. The plant medicinal composition can inhibit the angiogenesis in the breast cancer cells to achieve the effect of inhibiting breast cancers.