The invention discloses a full-automatic vacuum packaging machine which comprises a membrane releasing device, a printing device, a bag making device, a feeding device and a vacuum and sealing device connected in sequence. The vacuum and sealing device comprises a vacuum reciprocating mechanism, a vacuum switching mechanism, a bag receiving mechanism, a bag delivery mechanism, a traction mechanism, a sealing mechanism, a bag pressing and shaping mechanism, a bag clamp adjusting mechanism and a transfer belt separating mechanism. The vacuum reciprocating mechanism comprises a main box body capable of laterally moving and fixed side box bodies located on both sides of the main box body, and the main box body laterally moves to be combined with one side box body to form a vacuum chamber and simultaneously to be separated from another side box body to form an opened sealing station. The vacuum switching mechanism is used for vacuumizing and relieving the vacuum of the vacuum chamber and the sealing station. The bag receiving mechanism, the bag delivery mechanism, the traction mechanism, the sealing mechanism, the bag pressing and shaping mechanism, the bag clamp adjusting mechanism and the transfer belt separating mechanism are respectively located on both sides of the main box body. Packaging, inputting and outputting can be carried out at the same time, so that the efficiency isgreatly increased.