The invention discloses a safe radio frequency identification system comprising an antenna A (4), an antenna B (7), a radio frequency channel module (8), a control processing module (9), an integrity memory unit (10), a verification unit B (12), an identity authentication unit (17) and an integrity verification unit (18), wherein the antenna A (4) is respectively connected with a chip (5) and a verification unit A (6) in a bidirectional mode; the antenna A (4) is connected with the antenna B (7) in a wireless radio frequency mode; the safe radio frequency identification system finishes the safe bidirectional identity authentication among a background application system (3), a reader (2) and a label (1) and establishes radio frequency identification network connection mutually trusted; and the background application system (3) finishes the integrity verification of the information of the label (1) and the reader (2) after establishing the connection. The invention provides two levels of safe protection, and the information is transmitted in a cipher text mode so as to guarantee the reality, the integrity and the confidentiality of the transmission information.