The invention relates to a solvent-containing high-temperature corrosion-resistant flame-resistant anti-fouling thermoplastic resin, which is formed by performing a synthetic reaction of an epoxy resin and a saturated diacid with presence of a catalyst and a polymerization inhibitor (phenols), and being diluted with the solvent, the technology brings in the saturated diacid, the thermoplastic resin prepared according to the invention has performances of good shock resistance, corrosion resistance, high-temperature resistance and the like. Top long-term use temperature of the resin can be 460 degrees centigrade, top short-term use temperature thereof can be 600 degrees centigrade, and top bonding strength thereof can be 12MPa, a resin layer has the anti-fouling performance, and a fouling factor thereof is 1/50 of a stainless steel. With so many high-temperature resistant groups and phenols groups in the resin, the resin has good flame-resistant performance, a flame retardant index achieves the secondary level; the synthesis technology is simple and environmental-friendly, there is no the three wastes (waste gas, waste water and industrial residue), and products have good stability.