The invention discloses a liquor preparing machine for hemodialysis concentrated liquor. In the machine, a liquor preparing barrel the top of which is closed is arranged on a rack; the top of the liquor preparing barrel is provided with a feed inlet; a water adding pipe is arranged beside the liquor preparing barrel, is communicated with the inside of the liquor preparing barrel and is connected with a first solenoid valve in series; the bottom of the liquor preparing barrel is provided with a water outlet hole; the bottom parts of the liquor preparing barrel at two sides of the water outlet hole are respectively provided with a water return hole; the rack on the lower part of the liquor preparing barrel is provided with a water pump; the water pump is driven by a motor, and the water inlet of the water pump is communicated with the water outlet hole of the liquor preparing barrel by a water outlet pipe; the water outlet of the water pump is connected with a three-way pipe; one water outlet of the three-way pipe is connected with the water return pipe which is communicated with the corresponding water return hole of the liquor preparing barrel; the other water outlet of the three-way pipe is connected with a finished liquor outputting pipe and a disinfectant discharging pipe; and the disinfectant discharging pipe is connected with a second solenoid valve in series, and the finished liquor outputting pipe is connected with a valve in series. In the invention, the hemodialysis concentrated liquor which is not polluted by bacteria can be prepared under the hermetic and sterile condition.