The invention relates to a medicament for easing the pain of a human body and a preparation method thereof, in particular to a medicament composition with the functions of promoting blood circulation and removing blood stasis, resisting inflammation and diminishing swelling and easing pain, and a preparation method thereof. The medicament composition comprises the raw materials as follows: 20-100parts by mass of Chinese teasel root, 20-110 parts by mass of cape jasmine fruit, 10-100 parts by mass of Baikal skullcap root and 20-100 parts by mass of angelica root. The preparation method of themedicament composition comprises the following steps of: extracting the raw materials of the medicament composition with water or an ethanol solution, filtering, and collecting the filtrate to obtainthe medicament composition, wherein the percent of the ethanol in the ethanol solution by volume is more than 0 and less than or equal to 85%, and the mass ratio of the raw materials to the water or the ethanol solution is 1: 5-8. Clinical experiments show that the medicament composition has good curative effect for easing the neck/shoulder pain, the lumbocrural pain, the joint pain and the muscle pain caused by the rheumatism, the osteoproliferation, tumble and sprain, and the like.