The invention belongs to the field of medicine preparation, and in particular relates to a method for extracting mangiferin and total saponins of rhizoma anemarrhenae from rhizoma anemarrhenae, which mainly comprises the following steps of: water or diluted alcohol extraction, condensation, alcohol precipitation, filtering, dry by distillation and re-crystallization. The separation process related to the invention has the advantages of simplicity and convenience, economical efficiency and reliability.