The invention relates to an oxygen inhalation terminal with a replaceable nose plug and a connecting method thereof. The oxygen inhalation terminal with the replaceable nose plug comprises the nose plug, an oxygen delivery pipe and a transition connecting part, wherein the nose plug is connected with the transition connecting part in an elastic deformation way; the nose plug can be independently replaced as required at random; and the invention has the advantage of simple step, reduces an iatrogenic infection risk which is probably caused by the reason that the nose plug is not replaced in time, guarantees the safety of a patient and saves materials. The unique lacing design of the transition connecting part ensures the stability of the nose plug in the oxygen inhalation process and realizes true one-time use of the nose plug.