The invention provides a simulated experiment device of a three-dimension radial flow sieve tube, which comprises a sieve tube, a liquid supply system, a temperature control system and an analysis system. The sieve tube is arranged in a kettle body, a fluid inlet is arranged on the kettle body, a fluid outlet is arranged on the sieve tube, and a sand body is filled between the sieve tube and the fluid inlet; the liquid supply system comprises a pressure-controlled pump, an outlet of the pump is connected with the fluid inlet through an input pipeline, and an inlet of the pump is connected with a fluid outlet through an output pipeline; the temperature control system comprises a heater arranged on the input pipeline and an insulation box surrounding the kettle body; and the analysis systemcomprises a data acquisition unit for acquiring fluid information and a data processing unit connected with the data acquisition unit and used for processing and displaying fluid information. The liquid supply system is adopted to control simulated pressure, the temperature control system is adopted to control simulated temperature, the analysis system is adopted to acquire and output the data, and the position of the sieve tube is adjusted to adjust the sand body in the kettle body, thus various underground environments can be simulated comprehensively and truly to do experiment on the sievetube.