The invention relates to a mixture for treating depression. The mixture for treating depression is prepared from the following bulk pharmaceutical chemicals in parts by weight: 88-128 parts of radix bupleuri, 88-128 parts of angelica sinensis, 88-128 parts of radix paeoniae alba, 88-128 parts of rhizoma atractylodis macrocephalae, 88-128 parts of Indian buead, 70-110 parts of liquorice, 70-110 parts of mentha haplocalyx, 70-110 parts of rheum officinale, 160-200 parts of dragon's bones, 160-200 parts of concha ostreae, 160-200 parts of ruddle and 70-110 parts of mirabilite. The invention alsoprovides an application of the mixture for treating depression. The mixture has the advantages that purely natural traditional Chinese medicine raw materials are used; compatibility of medicines in the whole formula meets the assistant and guide principle of the traditional Chinese medicines; pharmacodynamics experiment proves that the mixture has the obvious efficacies of regulating the flow of vital energy, removing obstruction toit, soothing the nerves, stabilizing wills, and soothing liver-qi stagnation, and has better effect on manic depressive disorder, the depression and anxiety disorder; and the mixture is simple and convenient to prepare, and is suitable for being taken for a long term.