The invention discloses a portable refrigeration device, comprising a box body (1), a thermal insulation cover (2) and a thermal insulation layer (5); a refrigeration layer (6) is arranged in the thermal insulation layer (5), a refrigeration agent is filled in the refrigeration layer (6), a refrigeration room (7) is arranged in the refrigeration layer (6), ice and salt which are separated at the left side and the right side or are separated alternately in sequence are put in the refrigeration layer, a movable separating plate (11) is arranged between the ice and salt, the separating plate (11) is fixed in grooves (10) in a separating way, and the grooves (10) are distributed around the refrigeration layer in different proportions. The separating plate is taken out when the portable refrigeration device is used, the ice and the salt layers are contacted to be mixed, and the low temperature is rapidly generated after the ice and the salt are mixed. The cost of the portable refrigerationdevice is cheap, and the refrigeration agent can be recycled, no environmental pollution is caused, meanwhile, the refrigeration effect of the portable refrigeration device is rapid, the refrigeration duration is long, the production cost is low, and the product weight is light, therefore, the portable refrigeration device is easy to popularize in the society, and is a revolutionary product in the refrigeration industry.