The invention provides a traditional Chinese medicine composition with antibacterial and antiphlogistic effect, which is prepared from 76.5-261.45 parts of rhubarb, 45-107.1 parts of rhizoma imperatae, 22.5-50.4 parts of licorice, 5-10 parts of pharmaceutically acceptable chloride ion neutralizer, 10-15 parts of pharmaceutically acceptable heavy-metal chelating agent, 15-30 parts of acid agent, 20-40 parts of alkali agent and 2-5 parts of pharmaceutically acceptable lubricant, wherein the acid agent and the alkali agent are pharmaceutically acceptable disintegrating agents. The rhubarb, the rhizoma imperatae and the licorice with meridian tropism in lung and stomach are traditional Chinese herbal medicine, taste bitter and sweet, are cold in nature and have antibacterial and antiphlogistic effect. In addition, the rhubarb, the rhizoma imperatae and the licorice mutually compensate and have obvious effect on treating respiratory diseases, gastrointestinal infections and other diseases of livestock and poultry, and the livestock and the poultry can not be easily resistant to the traditional Chinese medicine composition.