The invention provides a pipe made of high-strength and high-tenacity X90 thick wall seamless pipeline steel tube and a manufacturing method thereof, and the steel type comprises the following elements in percentages by weight: 0.08-0.12% of C, 0.20-0.32% of Si, 1.25-1.35% of Mn, less than or equal to 0.015% of P, less than or equal to 0.010% of S, 0.016-0.042% of Al, 0.03-0.05% of Nb, 0.05-0.07%of V and 0.12-0.18% of Cu, wherein the contents of Cr, Mo and Ni elements in the steel are determined according to the wall thickness value of a steel pipe, the balance of are ferrum, and a trace amount of impurity elements. The invention also provides a production method of the rolling and heat processing of the seamless pipeline steel. The invention has the beneficial effects that a micro-alloying technique is adopted; the seamless pipeline steel is suitable for the production of a thick wall pipeline of the wall thickness below 50mm; a pipe body integrative structure is a uniform temperingbainite structure; the carbon equivalent is low; the welding properties are good; the low-temperature impact properties are excellent; the requirements for the thick wall pipeline of deep sea or other cold weathers are achieved; the hardenability of the steel is enhanced in the process of water cooling; and the mechanical properties of a pipeline are enhanced.