The invention discloses a health-care drink using sweet potato stem leaf extract as a main ingredient and a preparation method thereof. The health-care drink comprises the following raw materials in percentage by weight: 80 to 95 percent of fresh sweet potato stem leaves, 0.9 to 3.1 percent of fresh Chinese wolfberry, 0.9 to 3.1 percent of fresh tea tree leaves, 0.2 to 1.0 percent of isohydria salt and 0.5 to 5.0 percent of fresh fruits. The health-care drink is prepared by processes of material screening, sterile juicing, blending, filling, sterilizing and the like. The health-care drink is rich in various nutritional health-care ingredients, is mellow in mouthfeel, integrates the functions of the supply of organism energy, the maintenance of isohydria and the prevention of serious diseases into a whole, is suitable to be drunk by people in each age group, and particularly has the excellent effects of health care and the improvement of physical condition on people who suffer from sub-health trouble. The preparation method of the health-care drink is convenient for large-scale industrial production.