The invention relates to a high-efficient anti-stress agent for aquaculture. The high-efficient anti-stress agent is prepared from the following raw materials by weight percent: 5-10% of vitamin C phosphate magnesium, 20-40% of spirulina powder, 10-20% of betaine, 3-5% of taurine, 10-20% of sodium humate and 20-40% of glucosum anhydricum. The high-efficient anti-stress agent has the advantages that the raw material source is stable, the preparation method is simple, the cost is lower, the grazing rate, immunity and oxidation resistance of aquatic livestock are increased, the powder survival rate is increased, the growth is promoted, the economic benefit of the aquatic livestock is increased, and the environment pollution is prevented.