The invention relates to a secondary printing overprint control device for a printing machine. A photoelectric eye and a tension sensor are sequentially arranged between a first color printing plate and a secondary printing traction roller; the tension sensor is connected with a servo control device by a tension amplifier; the secondary printing traction roller is connected with the servo control device by a servo motor and a servo driver; the photoelectric eye is connected with an overprint control device; the first color printing plate roller is connected with the overprint control device by the servo motor, the servo driver B and program guidance (PG) simulation; and the servo control device and the overprint control device are mutually connected with a human-computer interface. In the secondary printing overprint control device, the overprint control device receives a PG simulation signal of the servo driver of a first color printing unit, performs position comparison on the simulation signal and a color code signal obtained by the photoelectric eye, and after passing through the deviatoric comparison, a control signal is sent to the servo control device to obtain a speed accurate adjustment value, so the aim of controlling the relative position of body paper color codes and plate roller color codes is realized.