The invention relates to an air vibration type expectoration instrument which belongs to the technical field of medical devices. The air vibration type expectoration instrument comprises a housing, an air chamber, a first drum membrane disc, a second drum membrane disc, a power machine, an induced draft mechanism, a drum membrane disc actuating mechanism, a vent pipe and a wearing device, whereinthe housing comprises a frame; the air chamber is enclosed by a first side plate, a second side plate, a third side plate, a fourth side plate, a top plate and a bottom plate, an air cavity is formedin the air chamber, a first drum membrane disc cavity is formed on the first side plate, and a second drum membrane disc cavity is formed on the second side plate; the first drum membrane disc is assembled on the first drum membrane disc cavity; the second drum membrane disc is assembled on the second drum membrane disc cavity; the power machine is fixed on the bottom plate or the frame, and a power shaft of the power machine probes into the air cavity; the induced draft mechanism is fixed on the frame and communicated with the air cavity; the drum membrane disc actuating mechanism is positioned in the air cavity and connected with the power shaft; and the wearing device is used for enabling a patient to wear, one end of the vent pipe is communicated with the air cavity, the other end of the vent pipe is matched and connected with the wearing device, and blocking materials are arranged in the air cavity. The air vibration type expectoration instrument has the advantages that the powerof the induced draft mechanism can be reduced under the premise of not affecting the drum membrane disc actuating mechanism; and the air vibration type expectoration instrument is not fastidious in using occasions, and can reduce the labor intensity of staff implementing treatment, and be conductive to expectoration.