The invention discloses a method for preparing an anti-polluting efficient oil-water separation ultra-filtration membrane, which comprises the following steps of: dissolving 16.0 mass percent of cellulose acetate into an N,N-dimethyl formamide solvent based on 100 percent of the mass of membrane casting solution, adding 15.0 to 30.0 mass percent of ethyl orthosilicate, and scraping a nascent state membrane with thickness of 240 microns on a glass plate; placing the nascent state membrane in the air for 10 to 30 seconds, and then soaking the nascent state membrane into gel baths of 25 DEG C, wherein the gel baths are aqueous solution of hydrochloric acid and aqueous solution of sodium hydroxide respectively; and taking out the membrane from the gel bath, placing the membrane into deionizedwater, and changing the water once every 5 hours to obtain the CA(TEOS)-HCl and CA(TEOS)-NaOH modified ultra-filtration membrane. The method is simple in process and mild in conditions; and the flux of the modified membrane is greatly improved, good anti-polluting performance is kept, and the modified membrane has high interception rate and can be used for treating oil-containing wastewater.