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CN102086196B 一种氨曲南的方法 失效 - 权利终止 转让

一种氨曲南的方法
摘要：
本发明涉及一种包括如下处理步骤的精制氨曲南的方法：步骤1)，在合适的溶剂或溶剂混合物存在下，在加热下用碱金属或碱土金属烷氧化物处理原料氨曲南，然后用合适的酸调节pH值，降温，析出氨曲南沉淀，获得初级提纯的氨曲南；步骤2)，用强碱性离子交换树脂对氨曲南进行吸附，然后洗脱，收集洗脱液，减压浓缩，获得二级提纯的氨曲南；步骤3)，用合适的酸调节pH值，进行结晶，将析出的晶体离心洗涤，干燥，获得三级提纯的氨曲南。本发明方法所得到的氨曲南精制品的纯度不低于99.2％，大部分不低于99.5％，而且炽灼残渣极少，重金属含量极低。
摘要（英）：

The invention relates to a method for refining aztreonam, comprising the following processing steps: 1) in the presence of an appropriate solvent or solvent mixture, processing raw material aztreonam by using alkali metal or alkaline-earth metal oxide under the condition of heating, regulating the pH value with proper acid, cooling, separating out aztreonam precipitate so as to obtain the primarily purified aztreonam; 2) absorbing the aztreonam with strong alkaline ion-exchange resin, then eluting, collecting eluent, and concentrating at reduced pressure, so as to obtain secondary purified aztreonam; and 3) regulating the pH value with proper acid, crystallizing, centrifugally washing precipitated crystals, and drying, thus three-stage purified aztreonam is obtained. The purity of the refined aztreonam obtained by the method is not less than 99.2%, the purity of most refined aztreonam is not less than 99.5%, flaming residues are few, and the content of heavy metal is extremely low.

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