The invention discloses a ceftazidime and tazobactam sodium medicine composition liposome injection which comprises the following components in parts by weight: 3 parts of ceftazidime, 1 part of tazobactam sodium, 3-20 parts of liposome membrane material, 2.2-15 parts of additive, 5-20 parts of freeze-drying proppant and 1-3 parts of antioxidant. The ceftazidime and the tazobactam sodium are prepared into liposome, thus the stability of the preparation is greatly improved, the medicine quality is increased, and the toxic and side effects are reduced; and the ceftazidime and tazobactam sodium medicine composition liposome injection has a targeting property, so that the treatment effect is improved.