The invention discloses a multifunctional ink powder filling device for a regenerated powder cartridge box, which is characterized by comprising a bottle body, a powder-leakage prevention bottle plug, a powder filling nozzle and a bottle cover serving as a measuring cup at the same time, wherein the bottle plug is tightly matched and arranged on a bottle mouth of the bottle body and is externallyprovided with the powder filling nozzle, the inner and the outer peripheries of the powder filling nozzle are respectively provide with inner threads matched with the outer threads of the bottle mouth and outer threads matched with the inner threads on the mouth part of the bottle cover, and the upper end of the powder filling nozzle is provided with a diminishing heavy-caliber powder filling hopper. The multifunctional ink powder filling device has the advantages that one bottle of ink powder can be filled in the powder cartridge box in many times or can be filled for machines of various types; the bottle cover serves as the measuring cup at the same time so that powder can be quantitatively filled in the powder cartridge box, and the bottle cover is internally provided with a powder filling nozzle adaptive to the powder cartridge boxes with powder filling ports of different sizes; the residual powder left after powder filling each time can be sealed with the bottle plug so as to prevent the powder from caking during standing to influence the use of next time; the ink powder filling device has a larger volume, can be used for filling powder for the powder cartridge box in many times, has the advantages of low price, various functions and convenience for carrying and use, and brings convenience to in-site powder filling by personnel for regeneration of the powder cartridge box.