The invention discloses a method for arranging a large-size concrete cooling water pipe, comprising the following steps of: a. obtaining the temperature filed distribution condition of large-size concrete and drawing an isothermal chart of the temperature field by adopting a real-measuring or temperature field numerical simulating technology; b. arranging the cooling water pipe along an isotherm or close to the isotherm; arranging feeding water in an area with highest concrete temperature and arranging the distance between the water pipes according to the distance of the isotherm or approximate to the distance of the isotherm. According to the method for arranging the large-size concrete cooling water pipe, provided by the invention, the defect that the cooling water pipes are equidistantly arranged is overcome, the temperature difference inside the concrete can be effectively reduced, the temperature stress inside the concrete is reduced, the concrete is prevented from cracking and cracks of the concrete are limited in expanding.