The invention provides an advertisement server, an information center and a mobile advertisement issuing method, wherein the advertisement server comprises a receiving module, a first acquiring module, a second acquiring module and a transmitting module. The receiving module is used for receiving an advertisement acquiring request of an information center; the first acquiring module is used for acquiring the current cell that a target device is located according to the advertisement acquiring request; the second acquiring module is used for acquiring a pre-stored advertisement file of an advertisement area that the current cell is located; the transmitting module is used for transmitting the advertisement file to the information center so as to make the information center insert the advertisement file into information to be transmitted and transmitting the information to be transmitted of the advertisement file to the target device. By combining a cell technology with the mobile advertisement, the invention realizes the effect of improving the advertisement issuing precision by customizing the advertisement of a special cell. Meanwhile, the information center inserts the advertisement content into the content of normal information, and users can see the advertisement content when watching the normal information so that the acceptability of the advertisement is improved.