The invention discloses an efficient degerming method used during rapid production of a bulbus fritillariae cirrhosae compost. The method is mainly characterized in that a microbiological contamination material during the rapid production of the bulbus fritillariae cirrhosae compost is degermed by adopting special steps according to the inhibition function of antibiotics to the bacterium growth. The special steps include selection of the microbiological contamination material, preprocessing, liquid degerming, first solid degerming, secondary solid degerming and degerming detection. According to the invention, the bacterium contamination during the production of the bulbus fritillariae cirrhosae compost is effectively eliminated under the condition of no damage on the compost, and the maximum degerming rate is up to 92.7 percent.