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发明授权
CN102100915B 一种苯丁酸氮芥多重靶向载药系统及其制备方法和应用 失效 - 权利终止

一种苯丁酸氮芥多重靶向载药系统及其制备方法和应用
摘要：
本发明涉及一种肿瘤细胞多重靶向载药系统、该载药系统的制备方法及该载药系统在抗肿瘤药物方面的利用，由PEG-HA-CHL组分和Fe3O4磁流体组分按重量比为1∶1-5的比例混合配制而成，其中，PEG-HA-CHL组分的组分含量按重量份数计为：苯丁酸氮芥20-100，PEG500-1500，HA100-500，DCC10-50，DMAP 1-10，丁二酸酐100-500，EDC 10-50，亚硫酸氢钠20-100。本发明的有益效果在于：系统药物释放的智能性；系统的多重靶向性和良好的逆转耐药作用；系统药物释放的控释性；系统良好的血液循环稳定性；系统良好的隐形性；系统的广泛适用性。
摘要（英）：

The invention relates to a chlorambucil multi-targeting medicine carrying system and a preparation method and application thereof in the aspect of anti-tumor medicines. The chlorambucil multi-targeted medicine carrying system is prepared by mixing a PEG-HA-CHL (polyethylene glycol-hyaluronic acid-chlorambucil) component with an Fe3O4 magnetofluid component in weigh ratio of 1:(1-5), wherein the PEG-HA-CHL comprises the following components in parts by weight: 20-100 parts of chlorambucil, 500-1500 parts of PEG, 100-500 parts of HA, 10-50 parts of DCC (dicyclohexylcarbodiimide), 1-10 parts of DMAP (dimethylamino pyridine), 100-500 parts of butanedioic anhydride, 10-50 parts of EDC (dichloroethane) and 20-100 parts of sodium hydrogensulfite. The invention has the advantages of intelligent medicine release, multiple targeting and better reverse medicine resistance, controlled medicine release, better blood circulation stability, better invisibility and wide applicability.

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