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CN102101864A 三宝木内酯A-D,其药物组合物,制备方法和应用 有权

三宝木内酯A-D,其药物组合物,制备方法和应用
摘要：
提供由结构式(I)所示的三宝木内酯A-D(Trigonolactone A-D，1-4)，为化学结构新颖的大环二萜内酯，具有显著的HIV-1诱导C8166细胞形成合胞体抑制活性，治疗指数(TI)在1848-13484范围，可作为抗艾滋病病毒(HIV)的药物。Trigonosteliimone A(1)R1＝Cl R2＝HTrigonosteliimone B(2)R1＝H R2＝H
摘要（英）：

The invention provides Trigonolactone A-D shown as a structural formula (I). The Trigonolactone A-D is macrocyclic diterpenoids with a novel chemical structure has remarkable HIV-1 (Human Immunodeficiency Virus 1) induction C8166 cell formation synplasm suppression activity, has the therapeutic index (TI) of between 1848 and 13484, and can be taken as an anti-human immunodeficiency virus (HIV) drug. In Trigonostelliimone A(1), R1 is Cl; and R2 is H; and in HTrigonostelliimone B(2), R1 is H and R2 is H.

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