The invention discloses a method for making watermelon health-care wine. The formula of the watermelon health-care wine comprises the following components in percentage by weight: 80 to 90 percents of watermelon flesh, 9 to 17 percents of pure grain wine, 1 to 3 percents of white sugar, 0.03 to 0.06 percent of precipitator and 0.06 to 0.08 percent of preservative, wherein the sum of the percentages of the above components is 100%. The making method comprises the steps of washing non-damaged and non-rotted watermelon, taking the flesh, crushing the flesh, placing the flesh and white sugar in a container, uniformly stirring till the flesh become liquid, soaking for 30 days with stirring every three days, removing slag, uniformly mixing with pure grain wine according to a component mixing ratio, adding the precipitator and the preservative, storing in a constant jar for 7 to 10 days and thus obtaining the watermelon health-care wine. In the invention, because the watermelon contains various nutrients such as proteins, amino acids and vitamins, particularly rich micro element 'selenium', the health-care wine made from the watermelon has cancer-preventing, anticancer, fitness-keeping and health-care effects. The wine has the fragrance of wine and is suitable for men and women of all ages and a good product for entertaining guests and to be given as a gift.