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发明公开
CN102105489A 人C组轮状病毒样颗粒的表达和组装及其应用 无效 - 驳回

人C组轮状病毒样颗粒的表达和组装及其应用
摘要：
C组轮状病毒(Group C rotaviruses)是儿童和成人中急性肠胃炎的导致原因，与A组RV截然不同。然而，人C组轮状病毒不能在培养基中生长，导致缺乏用于检测和治疗GrpC RV疾病的工具。因此，GpC RV疾病负担还没有清楚确定。根据本发明的具体实施例，提供了分离的重组人轮状病毒C组病毒样颗粒，以及除了别的以外，它们的生产方法和在Grp C RV感染检测、诊断分析和免疫原性组合物中的用途。
摘要（英）：

Group C rotaviruses are a cause of acute gastroenteritis in children and adults that is distinct from group A RV. However, human group C rotaviruses cannot be grown in culture, resulting in a lack of tools for detection and treatment of GrpC RV disease. Consequently, the burden of GpC RV disease has not been clearly established. Isolated recombinant human rotavirus group C virus-like particles are provided according to embodiments of the present invention along with methods of their production and use in, inter alia, detection of Grp C RV infection, diagnostic assays and immunogenic compositions.

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