The utility model relates to a sterilization composite containing azoxystrobin and application. The composite mainly comprises two compounds A and B with effective quantity, the A is the azoxystrobin, the B is selected one from myclobutanil, flusilazole, mancozeb and dimethomorph, and the compounds A and B have the following parts by weight: 50-1 and 1-50. The composite can be used for preventingand curing powdery mildew, rust disease, downy mildew, anthracnose, phytophthora infestans, leaf spot, cladosporium cucumerinum and the like on frumentum, vegetables and fruit trees, and particularlyhas good effect on sigatoka, erysiphe graminis, phytophthora capsici leonian, cucumber downy mildew and venturia nashicola.