The invention provides a medicament packing cork composite film and a manufacturing process thereof. The film consists of a surface layer, an intermediate layer and an inner layer, wherein the surface layer and the intermediate layer are mainly made of a thermoplastic elastomer, polyolefin and Teflon nano-powder; and the inner layer is made of a thermoplastic elastomer, polyolefin and a tackifying compatibilizer. The method for processing and forming the composite film for the medicament bottle cork comprises the following steps: metering the raw materials of each layer respectively; mixing and granulating; and manufacturing the film by virtue of a three-layer co-extrusion cast film forming unit or a film blowing unit. A nano-technology is applied to the film, so a medicament cannot be corroded and deteriorated by the cork, the quality guarantee period of the medicament is effectively prolonged; and the elasticity and elongation of the film and a rubber substrate are similar, so the product can be formed easily, the yield is high, the seal performance of the composite film cork is good, the film layer has less possibility of being separated, and application of the film cork and the sealing face of a bottle mouth has no special requirement, therefore, the composite film cork can be produced by utilizing conventional common mould equipment, energy and investment are saved, and the composite film is favorable for popularization and application.