The invention relates to a replaceable toothbrush with combination of multiple bristle sheets, comprising a first handle body, a second handle body and an integrated bristle sheet, wherein the first handle body and the second handle body can be mutually combined and connected; the integrated bristle sheet is clamped and fixed by the first handle body and the second handle body and composed of a plurality of bristle sheets; and the number of the bristle sheets of the integrated bristle sheet and the bristle type of each bristle sheet can be set according to tooth cleaning requirement so as to respectively provide different cleaning and nursing functions; and in addition, when the bristles on the bristle sheets reach the replacement degree, the integrated bristles sheet only needs to be replaced partially, therefore, the replaceable toothbrush with combination of multiple bristle sheets is economical and environment-friendly.