The invention relates to a method for separating zinc and indium and iron from indium-enriched high-iron high-zinc calcine through reduction-magnetic separation, belonging to the technical field of mineral processing. The invention is characterized in that the method adopts the technical means that mineral dressing is combined with smelting and performs smelting firstly and mineral dressing secondly; and the method is as follows: the waste heat of the indium-enriched high-iron zinc calcine obtained through fluidized roasting is utilized, the indium-enriched high-iron zinc calcine is introduced to perform low-temperature weak reduction treatment at below 570 DEG C and ensure that zinc ferrite is decomposed and reduced to ZnO, Fe3O4 and iron, the reduced calcine is levigated to prepare slurry, and zinc and indium and iron is separated through wet-type magnetic separation to obtain iron ore concentrates and indium-enriched zinc- enriched ore concentrates. The method has low energy consumption and low dosage of a reducing agent, is simple in operation, easy in control and high in metal recovery rate. Therefore, the indium embedded and distributed in zinc ferrite can be released, the loss caused by the high temperature volatilization of indium can be avoided, and the zinc and indium and iron of the indium-enriched high-iron high-zinc calcine can be separated in an ore dressing manner before leaching.