The invention discloses a 10kV power supply region intelligent control system, comprising a signal data acquisition circuit, a signal data calculation judgment circuit, an equipment operation circuit, a failure processing method circuit, a wireless alarm transmission circuit and a wireless receiving circuit, wherein, the signal data is acquired from a region power supply system to be respectivelyconnected with the signal data calculation and judgment circuit and the wireless alarm transmission circuit; the output of the signal data calculation judgment circuit is respectively connected with the equipment operation circuit, the wireless alarm transmission circuit and the failure processing method circuit; the output of the failure processing method circuit is connected with the wireless alarm transmission circuit; the output of the equipment operation circuit is connected with the wireless alarm transmission circuit; and the wireless receiving circuit is connected with the equipment operation circuit. In the invention, a system is developed for detecting, protecting and remote controlling the real-time status and data of a power distribution transformer, a 10kV load switch and a 400V power distribution system by utilizing a computer technique, a monitoring technique, a control technique and a communication technique, which has a positive promotion effect on developing the power distribution intelligentization.