The invention discloses a method for destroying chloric persistent organic waste through iron and quartz sand high-energy ball milling. The method comprises the following steps of: 1, mixing iron powder and silicon dioxide into a reactant, wherein the silicon dioxide is 20 to 60-mesh quartz sand and the mass content of the quartz sand in the reactant is between 5 and 20 percent; and 2, adding thereactant in step 1 and the chloric persistent organic waste in a mass ratio of 15:1-40:1 into a sealed ball-milling jar of a ball mill for a ball-milling reaction, wherein the ball material ratio is in a range of between 30:1 and 60:1, and the reaction time is 4 to 8 hours. The treatment time of the method is reduced by 25 percent when the method is compared with the traditional calcium oxide process; and the method has the characteristics of high treatment efficiency, simple process, low cost and environment friendliness in the process.