The invention relates to a method for mix design of a hot-mix asphalt mixture produced with an intermittent mixer and is characterized in that: the process mix design method comprises the following steps of: mineral mix design, Marshall test, determination of optimal asphalt dosage or oil-stone ratio, mix design test, correction of optimal asphalt dosage or oil-stone ratio and determination of final process mixing proportions of minerals. The step of mineral mix design comprises the procedures of determining initial proportions and designing mineral mixing proportions. The mix design method provided by the invention maintains consistency between process mix design and target mix design, and achieves quantization and visualization of the comparison between process mix design and target mixdesign. The mix design method effectively prevents the problem of material overflow, reduces loss, increases the running efficiency of equipment, reduces the consumptions of asphalt and mineral powder, ensures the construction quality and reduces the construction cost.