The invention discloses a plaster and a preparation method of the plaster. The crude drugs of the plaster include: 55-65g of Strychnos, 85-95g of radi of x clematidis, 40-50g of frankincense, 40-50g of myrrh, 25-35g of dragon's blood, 40 -50g of angelica, 25-35g of pseudo-ginseng, 45-55g of Ligusticum wallichii, 45-55g of Rhizoma Wenyujin Concisum, 40-50g of safflower, 45-55g of Processed Radix Aconiti, 45-55g of Processed Radix Aconiti Kusnezoffii, 55-65g of ephedra, 85-95g of cassia twig, 35-45g of notopterygium root, 35-45g of radix angelicae pubescentis, 55-65g of garden balsam stem, 45-55g of lycopodium clavatum, 35-45g of Rhizoma Drynariae, 45-55g of radix dipsaci, 45-55g of Eupolyphaga, 25-35g of scorpio, 40-50g of lumbricus, 40-50g of pangolin, 40-50g of Asarum and 15-25g of borneol. The formula is unique, the production method is simple and the curative effect is notable.