The invention relates to an air sac buffering shock-absorbing transportation packaging box for fragile objects. The packaging box comprises a box body, a cover and a plurality of external air sacs which are filled in gaps among the objects in the box body, wherein the inner wall and the bottom surface of the box body are bonded with box wall air sacs; and the box body is provided with an air injection port communicated with the box wall air sacs. Compared with the prior art, the air sac buffering shock-absorbing transportation packaging box for the fragile objects has a reasonable structure and appearance, is convenient to use, has a buffering shock-absorbing effect on the fragile objects during transportation, can be repeatedly used, and is suitable for process transportation of factories and object transportation of moving companies.