The invention relates to a fluorine-containing amphiphilic modified material for preparing an anti-pollution film and a preparation method thereof. The structural formula of the fluorine-containing amphiphilic modified material is disclosed in the specification. The preparation method comprises the following steps: adding (ethylene glycol)a-(methoxy propylene)b-(ethylene glycol)a block polymer and dodecafluoroheptyl methacrylate in a mol ratio into deionized water to obtain an emulsion; in a nitrogen atmosphere, adding an initiator ammonium ceric nitrate, and stirring to react, thereby obtaining a reaction solution containing the product; and dehydrating the reaction solution, removing impurities, and drying to obtain the fluorine-containing amphiphilic modified material. The preparation method has the advantage of mild process conditions and is simple to implement; and when the prepared fluorine-containing amphiphilic modified material is used for preparing the anti-pollution film, the film has superior properties.