The invention provides a smoke purification process capable of integrally desulphurizing, denitrifying and removing heavy metals and a device capable of realizing the process. According to the process, absorption liquid is sprayed in one absorption tower to remove sulfur dioxide, nitric oxide and heavy metals from smoke, wherein the adsorption liquid is an aqueous solution containing a desorption absorbent, and the desorption absorbent is the mixed liquid of ammonia water and a heavy metal trapping agent. The smoke purification device capable of integrally desulphurizing, denitrifying and removing heavy metals comprises an absorption tower, an ammonia supplying device, a heavy metal trapping agent feeding device and an ozone feeding device, wherein the ammonia supplying device and the heavy metal trapping agent feeding device are communicated with the lower part of the adsorption tower; and the ozone feeding device is respectively connected with a smoke inlet pipeline and an aerator pipe arranged in the absorption tower. The novel smoke purification process used for purifying smoke has the advantages of small occupied area, high purification efficiency and high byproduct utilization value, thus the economical benefit and social benefit can be obviously improved.