The invention discloses a machine head driving mechanism of a computer-based flat knitting machine, belonging to the technical field of computer-based flat knitting machines. The machine head driving mechanism comprises a machine head connecting base, a synchronous belt clamping plate, a pair of cable clamping plates, a synchronous belt, a tow chain and a cable and is characterized in that one end of the machine head connecting base is fixedly connected with the machine head of the computer-based flat knitting machine, the synchronous belt clamping plate and the synchronous belt are fixed to the middle part of the machine head connecting base, the pair of cable clamping plats and the cable are fixed to the other end of the machine head connecting base, and the tow chain is further fixedlyconnected to the other end of the machine head connecting base. The machine head driving mechanism disclosed by the invention has the advantages of simplifying processes of manufacture, installation and maintenance, saving raw materials and presenting economical efficiency.