The invention discloses a seal structure of an oil-free vortex compressor. The seal structure comprises a vortex body, and is characterized in that the top of the vortex body is provided with a seal groove; the seal groove is internally and sequentially provided with a seal strip and a seal lining from top to bottom; high-elasticity silicon rubber is adopted for the seal lining; and a self-lubricating and high-abrasion-resisting filled polytetrafluoroethylene material is adopted for the seal strip. The seal structure provided by the invention does not requires oil for lubrication and seal, has the advantages of simple power consumption, reliable seal property and long service life, is convenient to maintain and replace, and has favorable popularization value.