The invention provides a chuihou powder preparation and a preparation method thereof, and the preparation is prepared by the following raw materials by weight: 70-80 of calcined borax, 70-80 of calcined plaster, 10-20 of cinnabar, 5-15 of borneol, and 2-8 of calculus bovis. The preparation method comprises the following steps: pulverizing cinnabar by a water grind processing method to obtain ultrafine powder which can be sieved by a 200-mesh sieve; uniformly mixing and gringding calcined borax and calcined plaster, and sieving the mixture by a 100-mesh sieve; well mixing the above three drugs, adding fine calculus bovis powder and borneol powder, mixing well, and storing the mixture in a sealed container to keep in reserve. The formula is used to treat stubborn diseases such as intractable swelling and pain in throat, oral ulcer, aphthous stomatitis, swelling and pain in gum, and the like; the special calcined plaster in the formula has the effects of astringing dampness, promoting granulation, astringing sores, and hemostasis, and can be used for the external treatment of persistent ulceration; by using calcined plaster combined with other four traditional Chinese medicine, the preparation has good curative effect on intractable oral and throat erosion.