Disclosed is a catalytic de-waxing catalyst, including a molecular sieve having a non-one-dimensional mesoporous structure, heatproof inorganic oxide matrix and hydrogenated metal components. The catalytic de-waxing catalyst is characterized in that: the heatproof inorganic oxide matrix comprises gamma-alumina which is obtained by calcining pseudo-boehmite, and the pseudo-boehmite includes pseudo-boehmite P1 which has an n value no less than 1.1 and no more than 2.5. n satisfies the relation of n=D(031)/D(120), wherein D(031) refers to the crystal grain size of the crystal face represented bypeak 031 in an XRD spectra of pseudo-boehmite crystal grains, D(120) refers to the crystal grain size of the crystal face represented by peak 120 in the XRD spectra, peak 031 refers to a peak whose 2theta is 34 to 43 degrees in the XRD spectra, peak 120 refers to a peak whose 2theta is 23 to 33 degrees in the XRD spectra, D satisfies the relation of D=Klambda/(Bcostheta), K is a Scherrer constant, lambda is the diffracted wave length of a target material, B is the half-peak width of a diffraction peak, and 2theta is the position of the diffraction peak. The catalytic de-waxing catalyst provided in the invention has better performance in de-waxing.