The invention relates to an effervescent tablet for enabling virus infection of cervical cancer precancerous lesion patients to turn negative, and a preparation method thereof. The invention provides the effervescent tablet which takes realgar as the main component and a plurality of compatible traditional Chinese medicines supporting the healthy energy and is specially used for treating cervical cancer and gynecological inflammation. The tablet is prepared by the following bulk drugs: realgar, sophorae flavescentis, common cnidium fruit, borneol, dandelion, alum, solanum nigrum, Chinese angelica, borax, sodium bicarbonate and citric acid.The invention also provides a preparation method of the effervescent tablet, comprising the steps of: primary screening of the realgar, extrusion puffing, ultrafine pulverization, proportional mixing of the pulverized realgar with the compatible traditional Chinese medicines pulverized individually, sealing through tabletting and plate pressing, thus obtaining the tablet. The effervescent tablet of the invention is convenient for use and obvious in effect. And the preparation method provided in the invention has low cost and high production efficiency, thus being suitable for extensive use.