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发明授权
CN102220335B 富含鸟嘌呤的核酸适体及其应用 有权

富含鸟嘌呤的核酸适体及其应用
摘要：
本发明公开了一种富含鸟嘌呤的核酸适体及其应用。核酸适体为如下1)-4)中的至少一种：1)SEQ ID NO：1所示的DNA分子；2)SEQ ID NO：2所示的DNA分子；3)SEQ ID NO：3所示的DNA分子；4)SEQ ID NO：4所示的DNA分子。本发明为癌症的治疗提供了一种核酸适体药物。与其它肿瘤化疗药物相比，核酸适体药物具有很多优势：抑制肿瘤细胞增殖的特异性、容易合成和修饰、无免疫原性、能快速的穿透组织和良好的代谢动力学。
摘要（英）：

The invention discloses a guanine-rich nucleic acid aptamer and its application. The guanine-rich nucleic acid aptamer is at least one of the following 1)-4): 1) DNA molecules shown in SEQ ID No: 1; 2) DNA molecules shown in SEQ ID No: 2; 3) DNA molecules shown in SEQ ID No: 3; and 4) DNA molecules shown in SEQ ID No: 4. The invention provides a nucleic acid aptamer drug for treating cancers. Compared with other chemotherapeutics for tumors, the nucleic acid aptamer drug has the advantages of inhibiting the specificity of tumor cell proliferation, being easy to synthesize and modify, no immunogenicity, penetrating tissues rapidly and good pharmacokinetics.

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